Synthesis of tritium, deuterium, and carbon-14 labeled (S)-N-ethyl-N-methyl-3-[1-(dimethylamino)ethyl]carbamic acid, phenyl ester, (L)-2,3-dihydroxybutanedioic acid salt (SDZ ENA 713 hta), an investigational drug for the treatment of Alzheimer's Disease

1997 ◽  
Vol 39 (8) ◽  
pp. 651-668 ◽  
Author(s):  
Grazyna Ciszewska ◽  
Heidi Pfefferkorn ◽  
Y. S. Tang ◽  
Lawrence Jones ◽  
Richard Tarapata ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Carbamic Acid ◽  
Investigational Drug ◽  
Acid Salt ◽  
Phenyl Ester ◽  
Carbon 14 ◽  
Ena 713

Safety and tolerance of ENA 713 in patients with Alzheimer's disease (AD)

1995 ◽  
Vol 37 (9) ◽  
pp. 643-644 ◽  
Author(s):  
N.R. Cutler ◽  
J.J. Sramek ◽  
R. Anand
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ena 713

Synthesis of carbon-14 and stable isotope labeled Avagacestat: a novel gamma secretase inhibitor for the treatment of Alzheimer's disease

2014 ◽  
Vol 57 (10) ◽  
pp. 600-605 ◽  
Author(s):  
Richard C. Burrell ◽  
John A. Easter ◽  
Michael P. Cassidy ◽  
Kevin W. Gillman ◽  
Richard E. Olson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stable Isotope ◽  
Gamma Secretase ◽  
Carbon 14 ◽  
Secretase Inhibitor ◽  
Gamma Secretase Inhibitor

Dose-dependent CSF acetylcholinesterase inhibition by SDZ ENA 713 in Alzheimer's disease

2009 ◽  
Vol 97 (4) ◽  
pp. 244-250 ◽  
Author(s):  
N. R. Cutler ◽  
R. J. Polinsky ◽  
J. J. Srarnek ◽  
A. Enz ◽  
S. S. Jhee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Acetylcholinesterase Inhibition ◽  
Dose Dependent ◽  
Ena 713

Safety/tolerability trial of SDZ ENA 713 in patients with probable Alzheimer's disease

Life Sciences ◽  
1996 ◽  
Vol 58 (15) ◽  
pp. 1201-1207 ◽  
Author(s):  
John J. Sramek ◽  
Ravi Anand ◽  
Thomas S. Wardle ◽  
Peter Irwin ◽  
Richard D. Hartman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ena 713

P-8-10 Safety and tolerance of ENA 713 in Alzheimer's disease (AD)

1995 ◽  
Vol 5 (3) ◽  
pp. 382-383 ◽  
Author(s):  
N.R. Cutler ◽  
J.J. Sramek ◽  
R. Anand
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ena 713

Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer’s disease

2002 ◽  
Vol 23 (2) ◽  
pp. 179-186 ◽  
Author(s):  
Mark A Lovell ◽  
J.David Robertson ◽  
Bruce A Buchholz ◽  
Chengsong Xie ◽  
William R Markesbery
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurofibrillary Tangles ◽  
Senile Plaques ◽  
Carbon 14

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

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